曲久鑫
  • qujiuxin@126.com

北京协和医学院病原生物学博士,研究员,硕士生导师,美国加州大学旧金山分校(UCSF)访问学者。现任深圳市第三人民医院检验医学部副主任(主持工作),从事临床微生物和分子测序检验、卫生科研、教学和实验室管理工作。

目前,担任中国医师协会检验医师分会第五届委员会委员,中华医学会结核病分会临床检验专委会常委,深圳市医学会检验专业委员会副主任委员(微生物专业学组组长)等,《中华检验医学杂志》青年编委。

 

研究方向:

致病细菌基因功能研究和病原体快速检测。

 

代表性论著:

1. Zhu, Q., Lin, Q., Jiang, Y. and et al.. (2023). Construction and application of the conditional essential gene knockdown library in Klebsiella pneumoniae to screen potential antimicrobial targets and virulence genes via Mobile-CRISPRi-seq. Applied and Environmental Microbiology. Accepted. (唯一通讯)

2. Chen, S., Liu, H., Li, T., Lai, W., Liu, L., Xu, Y., Qu, J.. (2023). Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis. Infect Drug Resist. 2023 Jul 3;16:4311-4323.

3. Wang, D., Wang, X., Ye, F., Zou, J., Qu, J*., & Jiang, X*. (2023). An Integrated Amplification-Free Digital CRISPR/Cas-Assisted Assay for Single Molecule Detection of RNA. ACS nano, 17(8), 7250–7256.

4. Li, Y., Zhang, W., Zhao, J., Lai, W., Zhao, Y., Li, Y.*, & Qu, J. *(2022). Mycobacterium paragordonae is an emerging pathogen in human pulmonary disease: clinical features, antimicrobial susceptibility testing and outcomes. Emerging Microbes & Infections, 11(1), 1973–1981.

5. Zou, J.#, Chen, S.#, Rao, W., Fu, L., Zhang, J., Liao, Y., Zhang, Y., Lv, N., Deng, G., Yang, S., Lin, L., Li, L., Liu, S.*, & Qu, J*. (2022). Population Pharmacokinetic Modeling of Bedaquiline among Multidrug-Resistant Pulmonary Tuberculosis Patients from China. Antimicrobial Agents and Chemotherapy, 66(10), e0081122.

6. Qu, J.#*, Wu, C.#, Li, X., Zhang, G., Jiang, Z., Li, X., Zhu, Q., & Liu, L.* (2020). Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America, 71(16), 2255–2258.

7. Chen, S.#, Zhu, Q.#, Xiao, Y.#, Wu, C., Jiang, Z., Liu, L., & Qu, J.* (2021). Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study. The Clinical Respiratory Journal, 15(7), 815–825. (高被引论文)

8. Jiang, Z., Chen, S., Zhu, Q., Xiao, Y., & Qu, J.* (2022). COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen City. Journal of Infection and Public Health, 15(2), 222–227.

9. Chen, Y., Zong, N., Ye, F., Mei, Y., Qu, J.*, & Jiang, X.* (2022). Dual-CRISPR/Cas12a-Assisted RT-RAA for Ultrasensitive SARS-CoV-2 Detection on Automated Centrifugal Microfluidics. Analytical Chemistry, 94(27), 9603–9609.

10. Qu, J.#, Cai, Z.#, Duan, X., Zhang, H., Cheng, H., Han, S., Yu, K., Jiang, Z., Zhang, Y., Liu, Y., Bai, F., Liu, Y., Liu, L.*, & Yang, L.* (2022). Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patients. Cell & Bioscience, 12(1), 14.

11. Qu, J.#, Prasad, N. K.#, Yu, M. A., Chen, S., Lyden, A., Herrera, N., Silvis, M. R., Crawford, E., Looney, M. R., Peters, J. M.*, & Rosenberg, O. S.* (2019). Modulating Pathogenesis with Mobile-CRISPRi. Journal of Bacteriology, 201(22), e00304-19.

12. Peters, J. M.*, Koo, B. M., Patino, R., Heussler, G. E., Hearne, C. C., Qu, J., Inclan, Y. F., Hawkins, J. S., Lu, C. H. S., Silvis, M. R., Harden, M. M., Osadnik, H., Peters, J. E., Engel, J. N., Dutton, R. J., Grossman, A. D., Gross, C. A.*, & Rosenberg, O. S.* (2019). Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nature Microbiology, 4(2), 244–250.

 

近年主持的与申请项目相关的各类国家、省、市科技计划项目情况:

近3年主持课题8项,合计研究经费共479万元:

1. 广东省科技厅,2020B1111170014,结核分枝杆菌耐药基因快速高通量分子诊断技术,主持,2021,92万

2. 广东省自然科学基金委员会,2020A1515010586,基于Mobile-CRISPRi技术构建肺炎克雷伯菌knockdown文库及其抗菌药物靶点筛选的研究,主持,2019.10-2022.09,10万

3. 深圳市科创委, JSGG20220301090206010, 抗疫专2022020高灵敏、便携式和全自动新冠抗原检测系统研发,分中心负责人,2022.03.23-2023.03.23,100万

4. 深圳市科创委,JSGG20220226090407011,抗疫专2022014全自动智能核酸采样机器人系统关键技术研发及应用,分中心负责人,2022.05.01-2023.04.30,200万

5. 深圳市科创委,JCYJ20190809144005609,JCYJ20190809144005609,基于Mobile-CRISPRi技术构建肺炎克雷伯菌knockdown文库及其抗菌药物靶点筛选的研究,2021, 10万

6. 吴阶平基金,320.6750.2021-06-23,基于化学发光免疫分析检测弓形虫 IgG 抗体亲合力的方法开发,主持,10万

7. 横向,传染性疾病检验项目及标记物临床性能验证及临床应用研究,主持,45万

8. 横向,中国广州和深圳新型冠状病毒流行期间不明原因肺炎流行病学研究,主持,12万

 

获得国家、省市级奖励情况:

北京市医管局青年医学人才(2015)、广东省杰出青年医学人才(2018)、广东青年五四奖章(2020)、深圳市高层次专业人才(2018)、十大深圳好青年(2019)和深圳青年五四奖章(2021)