研究方向：
黄曦教授从事抗感染免疫、抗肿瘤免疫、组织器官退行性病变的免疫机制，以及干细胞介导的免疫调控机制研究多年，分别从机体、细胞、分子等不同层面开展了一系列原创性研究，深入研究感染、肿瘤、退行性疾病的免疫病理与损伤机制，为寻找有效的药物作用靶点和免疫细胞与干细胞介导的防治措施提供科学的理论依据。
代表性论著（以下为论著目录节选）：
1. Jian Chen#, Tianchuan Zhu#, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang*. Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in Colorectal cancer. Molecular cancer. 2023, 22(1):131. (IF=41.444）
2. Xianjun Li#, Tianchuan Zhu#, Ronghao Wang#, Jian Chen, Lantian Tang, Wenwen Huo*, Xi Huang*, Qingdong Cao*. Genetically Programmable Vesicles for Enhancing CAR-T Therapy against Solid Tumors. Advanced materials. 2023, 35(19):e2211138. (IF=32.086)
3. Yongjian Wu, Qiaohua Wang, Miao Li, Juanfeng Lao, Huishu Tang, Siqi Ming, Minhao Wu, Sitang Gong, Linhai Li, Lei Liu, Xi Huang*. SLAMF7 Regulates Inflammatory Response In Macrophage During Polymicrobial Sepsis. Journal of Clinical Investigation. 2023, 133(6):e150224. (IF=19.456)
4. Ronghao Wang#, Tianchuan Zhu#, Bingzong Hou*, Xi Huang*. An iPSC-derived exosomes pulsed dendritic cell vaccine boosts antitumour immunity in melanoma. Molecular Therapy.2023, S1525-0016(23)00317-9. (IF=12.910)
5. Yang Yang#, Yongjian Wu#, Xiaojun Meng, Zhiying Wang, Muhammad Younis, Ye Liu, Peihui Wang, Xi Huang*. SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK. Cell Death & Differentiation. 2022, 1-14. (IF=15.828)
6. Bin Li#, Wei Wang#, Weifeng Song#, Zheng Zhao‡, Qingqin Tan, Zhaoyan Zhao, Lantian Tang, Tianchuan Zhu, Jialing Yin, Jun Bai, Xin Dong, Siyi Tan, Qunying Hu*, Ben Zhong Tang*, Xi Huang*. Antiviral and Anti-Inflammatory Treatment with Alveolar Macrophage-like Nanoparticles in a Surrogate Mouse Model of COVID-19. Advanced Science. 2021, 2003556. (IF=16.806)
7. Bin Li#, Dong Wang#, Michelle Mei Suet Lee#, Wei Wang, Qinqing Tan, Zhaoyan Zhao, Ben Zhong Tang*, Xi Huang*. Fabrics Attached with Highly Efficient Aggregation-Induced Emission Photosensitizer: Towards Self-Antiviral Personal Protective Equipment. ACS NANO. 2021, 15(8):13857-13870. (IF=15.881)
8. Yongjian Wu, Minhao Wu, Siqi Ming, Xiaoxia Zhan, Shengfeng Hu, Xingyu Li, Huan Yin, Can Cao, Jiao Liu, Jinai Li, Zhilong Wu, Jie Zhou, Lei Liu, Sitang Gong, Duanman He, Xi Huang*. TREM-2 promotes Th1 responses by interacting with the CD3z/Zap70 complex following Mycobacterium tuberculosis infection. Journal of Clinical Investigation. 2021, 131(17):e137407. (IF=14.808)
9. Yongjian Wu, Manni Wang, Huan Yin, Siqi Ming, Xingyu Li, Guangmin Jiang, Ye Liu, Peihui Wang, Guangde Zhou, Lei Liu, Sitang Gong, Haibo Zhou, Hong Shan, Xi Huang*. TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection. Science Advances. 2021, 7(50):eabi6802. (IF=14.136)
10. Kuai Yu#, Jingjing He#, Yongjian Wu#, Baosong Xie, Xuefei Liu,Bo Wei, Haibo Zhou, Bingliang Lin, Zhixiang Zuo,Wen Wen, Wenxiong Xu, Bin Zou, Lai Wei*, Xi Huang*, Penghui Zhou*. Dysregulated adaptive immune response contributesto severe COVID-19. Cell research. 2020, 30(9):814-816. （IF=25.617）
11. Yongjian Wu#, Cheng Guo#, Lantian Tang#, Zhongsi Hong, Jianhui Zhou, Xin Dong, Huan Yin, Qiang Xiao, Yanping Tang, Xiujuan Qu, Liangjian Kuang, Xiaomin Fang, Nischay Mishra, Jiahai Lu, Hong Shan*, Guanmin Jiang*, Xi Huang*. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterology & Hepatology. 2020, 5(5):434-435.（IF=18.486）
12. Yuhui Liao, Bin Li, Zheng Zhao, Yu Fu, Qingqin Tan, Xingyu Li, Wei Wang, Jialing Yin, Hong Shan, Ben Zhong Tang, Xi Huang*. Targeted Theranostics for Tuberculosis: A Rifampicin-Loaded Aggregation-Induced Emission Carrier for Granulomas Tracking and Anti-Infection. ACS Nano. 2020, 14(7):8046-8058.（IF=15.881）
主持基金：
1. 国家科技重大专项,结核病新型诊断产品研发及其产品化，编号2017ZX10302301-002，2017.01-2021.12，2288万元，主持
2. 深圳市第三人民医院高水平医院经费，结核病的免疫机制及其新型治疗策略研究，2023.1-2025.12，300万元，主持
3. 清远市人民医院医学科研基金，多功能仿生纳米囊泡介导的结核病精准治疗研究，2023.1-2025.12，200万元，主持
4. 佛山市第四人民医院“ 登峰计划”高水平医院建设项目，TREM-2调控细胞免疫介导的抗结核免疫新机制研究，编号FSSYKF-2020003，2020.6.1-2022.5.31，100万元，主持
5. 国家自然科学基金-面上项目，多功能仿生纳米囊泡介导的结核病精准治疗研究，编号 82072062，2021.1-2024.12，55万元，主持
获得奖励情况：
1. 新型冠状病毒肺炎临床救治的“珠海实践”，创新珠海科学技术奖，特等奖，2022年
2. 智慧制造的脐带间充质干细胞药物，第十届中国创新创业大赛（广东赛区）暨第九届“珠江天使杯”科技创新创业大赛生物医药行业，优胜奖，2021年
3. 结核病防治技术集成与应用研究，广东省科技进步奖，一等奖，2019年
4. 基于恒温实时荧光技术建立结核分枝杆菌快速检测产品研发及产业化，中国防痨协会科技技术奖，科技进步奖，2018年
5. 结核病新型诊断产品研发及产业化，第七届中国创新创业大赛(广东·广州赛区)，三等奖，2018年
